Abstract #4422
Changes in epithelium, stroma, and lumen space predict ADC changes with prostate cancer Gleason grade
Aritrick Chatterjee 1 , Geoff Watson 2 , Esther Myint 3 , and Roger Bourne 1
1
Faculty of Health Sciences, University of
Sydney, Sydney, NSW, Australia,
2
Tissue
Pathology and Diagnostic Oncology, Royal Prince Alfred
Hospital, Sydney, NSW, Australia,
3
Laverty
Pathology, Sydney, NSW, Australia
Reduced water ADC in cancer tissue is commonly
attributed to increased cellularity, however, this
explanation includes many assumptions about the
diffusion properties of tissue. We hypothesise that the
biophysical basis of reduced ADC in prostate cancer may
instead lie in an increased partial volume of low
diffusivity epithelial cells and loss of higher
diffusivity stroma and lumen space. Partial volumes of
epithelium, stroma, and lumen space were measured in
histology images. There was a significant increase in
epithelium volume and decrease in stroma and lumen space
with Gleason grade. Predicted ADC changes explained
about half the variation seen in vivo.
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