Abstract #4258
Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T2 suppression
Luning Wang 1 , Wei Tang 2 , Zipeng Zhen 2 , Hongming Chen 2 , Jin Xie 2 , and Qun Zhao 1
1
Department of Physics and Astronomy,
University of Georgia, Athens, Georgia, United States,
2
Department
of Chemistry, University of Georgia, Athens, Georgia,
United States
Iron oxide nanoparticles (IONPs) have been widely used
as a T2/T2* contrast agent in MRI. To avoid signal loss
caused by IONPs, pulse sequences, such as Ultrashort TE
(UTE) and Sweep Imaging with Fourier Transform (SWIFT),
can be implemented to acquire MR signals of IONPs, since
the echo times of these sequences are in a few
microseconds. But in the UTE and SWIFT images, long T2
tissues and fat may also appear bright, posing a
challenge to discriminate IONPs from surrounding
tissues. In this work, IONPs were used to target tumor
cells grafted in mice. In order to improve the detection
specificity of the IONPs delivered to tumors, we
hypothesized to embed saturation pulses into the SWIFT
sequence to suppress long T2 tissues and fat.
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