Abstract #4200
Understanding the Vascular Effect on Resting-State fMRI: a Multi-Modality Approach
David C Zhu 1 , Takashi Tarumi 2,3 , Muhammad Ayaz Khan 2,3 , and Rong Zhang 2,3
1
Departments of Radiology and Psychology,
Michigan State University, East Lansing, MI, United
States,
2
Institute
for Exercise and Environmental Medicine, Texas Health
Presbyterian Hospital Dallas, Dallas, TX, United States,
3
Department
of Internal Medicine, University of Texas Southwestern
Medical Center, Dallas, TX, United States
We used transcranial Doppler ultrasonography,
near-infrared (NIR) spectroscopy and resting-state fMRI
to demonstrate the presence of high-level coupling
between the vascular signal fluctuations driven by
cardiac activity and the fluctuations of resting-state
fMRI and NIR BOLD signals. Findings from the present
study raise a fundamental question of whether the BOLD
signals used to assess brain functional connectivity are
primarily due to the vascular effects produced from
upstream changes in cerebral hemodynamics. The results
demonstrate the importance and necessity to develop new
methods to uncover the BOLD signal due to spontaneous
neuronal activity from the strong vascular signal
contamination.
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