Abstract #4197
Latency time variability hinders ASL fMRI analyses
Joao M. S. Pereira 1 , Joo Duarte 2 , Miguel Raimundo 3 , and Miguel Castelo-Branco 4
1
Laboratory of Biostatistics, IBILI - Faculty
of Medicine, University of Coimbra, Coimbra, Portugal,
2
ICNAS
- Faculty of Medicine, University of Coimbra, Coimbra,
Portugal,
3
Clinical
School - Faculty of Medicine, University of Coimbra,
Coimbra, Portugal,
4
Visual
Sciences Laboratory, IBILI - Faculty of Medicine,
University of Coimbra, Coimbra, Portugal
For functional imaging purposes, Arterial Spin Labeling
(ASL) has the advantage of measuring activity directly
related to neuronal activation with greater localizing
sensitivity than the more common BOLD signal analyses.
The application of ASL in the fMRI context has, however,
been blighted by subpar performances. This work
addresses the variability of the latency in the
hemodynamic response function (HRF) in both healthy
controls and diabetes type II patients, known to have
changes in brain vasculature. A method is presented to
bypass this limitation in ASL fMRI.
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