Abstract #4187
Laminar Profile of Intracortical Resting-state Functional Connectivity
Russell W. Chan 1,2 , Shu-Juan J. Fan 1,2 , Patrick P. Gao 1,2 , Iris Y. Zhou 1,2 , Adrian Tsang 1,2 , and Ed X. Wu 1,2
1
Laboratory of Biomedical Imaging and Signal
Processing, The University of Hong Kong, Hong Kong,
China,
2
Department
of Electrical and Electronic Engineering, The University
of Hong Kong, Hong Kong, China
This study investigates the laminar interconnections in
the rat primary visual cortex (V1) and visualizes layer
specific neuroanatomy using resting-state fMRI (rsfMRI)
and manganese-enhanced MRI (MEMRI), respectively. The
rsfMRI results indicated that the V1 layers II/III and
layers V/VI are more functionally connected during
resting-state using seed-based and independent component
analyses, which could be associated with the
intracortical processing in V1 layers II, III, V and VI
during visual stimulation. We also demonstrated layer
specific manganese enhancement in the rat V1, revealing
the neuroanatomical structure. The laminar rsfMRI
connectivity may provide further insights in
intracortical and intrahemispheric neural communication.
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