Abstract #4151
Longitudinal functional connectivity changes in mild traumatic brain injury: correlation with diffusion, T2 and behavioral outcomes
Shiliang Huang 1 , Lora Talley Watts 1 , Justin Long 1 , Qiang Shen 1 , and Timothy Duong 1
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States
This study examined longitudinally the rsfMRI changes in
mild TBI of the (unilateral) primary somatosensory
cortex in rats during hyperacute and chronic phase up to
14 days. Quantitative correlations were made with T2,
DTI, fractional anisotropy (FA), and functional outcomes
(forelimb placement asymmetry and foot fault scores).
rsfMRI z-scores reduced after mild TBI but improved with
time. The trend of improvement parallels those of
behavioral scores. rsfMRI did not significantly
correlate with ADC and FA changes, suggesting they
provide complementary information. This study
demonstrated that rsfMRI offers novel insights into
functional connectivity in mild TBI.
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