Abstract #4114
Relationship between MR visible metabolites, MR imaging parameters and quantitative histopathology in prostate cancer
Kirsten Margrete Selns 1,2 , Riyas Vettukattil 1 , May-Britt Tessem 1,2 , Helena Bertillson 3,4 , Alan Wright 5 , Arend Heerschap 1,5 , Anders Angelsen 3,4 , and Tone Frost Bathen 1
1
Department of Circulation and Medical
Imaging, Norwegian University of Science and Technology,
Trondheim, Norway,
2
St.
Olavs Hospital, Trondheim University Hospital,
Trondheim, Norway,
3
Department
of Urology, St. Olavs Hospital, Trondheim University
Hospital, Trondheim, Norway,
4
Department
of Cancer Research and Molecular Medicine, Norwegian
University of Science and Technology, Trondheim, Norway,
5
Department
of Radiology, Radboud University Nijmegen Medical
Center, Nijmegen, Netherlands
Metabolic and morphologic changes due to prostate cancer
lead to changes in MR imaging and MR spectroscopic
parameters. This study aims to assess the relationship
between MRI parameters (T2 intensity and ADC) measured
on patients in vivo, individual metabolites measured on
prostatectomy tissue ex vivo with HR-MAS MRS and
quantitative histopathological features (percentage
nuclei and luminal space). ADC was positively correlated
to lumen and negatively correlated to amount of nuclei
( = 0.54 and -0.36 respectively, p<0.01). There is a
positive correlation between total choline and amount of
nuclei (=0.38, p<0.01) and between citrate and amount
of lumen (=0.37, p<0.01)
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