Abstract #4043
Anti-angiogenic therapy in a murine liver cancer: Complementary assessment with MR-Elastography and Diffusion-Weighted MR imaging
Lauriane Juge 1 , Miguel Albuquerque 2 , Mouniya MEBARKI 2 , Simon A. Lambert 2 , Sabrina Doblas 2 , Shaokoon Cheng 3,4 , Lynne E. Bilston 3,5 , Valerie Paradis 2,6 , Valerie Vilgrain 2 , Bernard E. Van Beers 2 , and Ralph Sinkus 2
1
Neuroscience Research Australia, Randwick,
Sydney, NSW, Australia,
2
CRB3-INSERM
U773, University Paris Diderot, Paris, France,
3
Neuroscience
Research Australia, Randwick, Sydney, Australia,
4
Engineering,
Macquarie University, North Ryde, Sydney, Australia,
5
Prince
of Wales Clinical School, university of New South Wales,
Kensington, Sydney, Australia,
6
Pathology,
Beaujon Hospital, Paris, France
Early detection of changes in the vascularity and
cellularity of a tumor could represent a significant
advance in treatment management using anti-angiogenic
agents. We investigated the potential value of MR-Elastography
(800, 900 and 1000 Hz) and Diffusion Weighted MR imaging
(6 b-values from 0 to 1000 s/mm) in the detection of
microstructural changes induced by the therapy (Sorafenib,
Nexavar ) in a human liver cancer cell line (HepG2)
implanted in immune-deficient mice.. Results showed that
potentially, only the biomechanical dispersion
properties were sensitive to the changes induced by the
anti-angiogenic treatment, while the apparent diffusion
properties were not altered.
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