Abstract #4004
Tracking Disease Progression in Duchenne Muscular Dystrophy: Longitudinal Changes in Quantitative MR Measures
William D. Rooney 1 , Sean C. Forbes 2 , William T. Triplett 3 , James R. Pollaro 1 , Dah-Jyuu Wang 4 , Soren deVos 2 , James Meyer 4 , Rebecca Willcocks 3 , Barry Byrne 5 , Richard Finkel 6 , Barry Russman 7 , Erika Finanger 7 , Michael Daniels 8 , Lee Sweeney 9 , Glenn Walter 3 , and Krista Vandenborne 2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Department
of Physical Therapy, University of Florida, Gainesville,
Florida, United States,
3
University
of Florida, Physiology and Functional Genomics,
Gainesville, Florida, United States,
4
Department
of Radiology, Children's Hospital of Philadelphia,
Philadelphia, Pennsylvania, United States,
5
Department
of Pediatrics, University of Florida, Gainesville,
Florida, United States,
6
Neurology,
Children's Hospital of Philadelphia, Philadelphia,
Pennsylvania, United States,
7
Shriners
Hospital, Portland, Oregon, United States,
8
University
of Texas, Austin, Texas, United States,
9
Department
of Physiology, University of Pennsylvania, Philadelphia,
Pennsylvania, United States
This study investigates the utility of quantitative MR
measures to track disease progression in DMD. 3T Data
were acquired from 125 DMD and 28 control boys.
1
H
MRS data were acquired to estimate fat fraction (FF) in
vastus lateralis (VL) and soleus (Sol) muscles. MRI
quantitative T
2
(qT
2
)
values were determined for muscles in the upper and
lower leg. DMD boys were studied at baseline, and 12
month and 24 month follow-ups. Both FF and qT
2
are
increased at follow-up with greatest absolute
differences found in upper leg muscles. MRI qT
2
values
were strongly associated with muscle FF.
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