Abstract #3987
Multi-Component T2 Analysis of Articular Cartilage in Osteoarthritis Patients using mcDESPOT at 3.0T
Fang Liu 1 , Richard G. Spencer 2 , Wally Block 1,3 , and Richard Kijowski 4
1
Department of Medical Physics, University of
Wisconsin-Madison, Madison, Wisconsin, United States,
2
Magnetic
Resonance Imaging and Spectroscopy Section, National
Institutes on Health, Baltimore, Maryland, United
States,
3
Department
of Biomedical Engineering, University of
Wisconsin-Madison, madison, Wisconsin, United States,
4
Department
of Radiology, University of Wisconsin-Madison,
Wisconsin, United States
Multi-Component T2 mapping using mcDESPOT two pool model
was performed for ten asymptomatic volunteers and
fourteen patients with varying degrees of
osteoarthritis. The water fraction for water tightly
bound to proteoglycan (FPG ) was significantly lower on
all articular surfaces of the knee joint in patients
with osteoarthritis than asymptomatic volunteers which
likely reflect the decreased proteoglycan content of
degenerative cartilage. FPG had greater statistical
power than single component T2 (T2single ) for
distinguishing between asymptomatic volunteers and
patients with osteoarthritis especially on articular
surfaces with early cartilage degeneration.
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