Abstract #3983
Clinical feasibility of a stimulated echo based diffusion sequence and correlation between T1rho and diffusion values
Aditi Guha 1 , Cory Wyatt 1 , Dimitrios Karampinos 1,2 , Lorenzo Nardo 1 , Thomas M Link 1 , and Sharmila Majumdar 1
1
Radiology and Biomedical Imaging, UCSF, San
Francisco, CA, United States,
2
Radiology,
Technische Universitt Mnchen, Germany
Osteoarthritis (OA) is a common degenerative disorder,
which occurs due to wear and tear of the joint. Research
has shown that subtle changes in tissue microstructure
correlate with changes in restricted diffusion of water,
which manifest in signal changes on diffusion-weighted
MR images. A new pulse sequence for diffusion weighted
imaging of the knee combining stimulated echo diffusion
preparation with magnetization prepared angle modulated
partitioned k-space spoiled gradient echo snapshots
(MAPSS) acquisition for diffusion imaging of short T2
tissues like cartilage at 3T is investigated. We also
look at the correlation between two potential biomarkers
for OA: diffusion and T1ρ.
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