Abstract #3961
Cardiac ECV is More Robust than Post-Contrast Cardiac T1 for Evaluating Temporal Changes in Left Ventricular Fibrosis
Kyungpyo Hong 1,2 , Matthias Koopmann 3 , Eugene G. Kholmovski 1 , Eric C. Huang 4 , Nan Hu 5 , Richard Levenson 4 , Sathya Vijayakumar 1 , Derek J. Dosdall 6 , Ravi Ranjan 6 , and Daniel Kim 1
1
UCAIR, Department of Radiology, University
of Utah, Salt Lake City, Utah, United States,
2
Department
of Bioengineering, University of Utah, Salt Lake City,
Utah, United States,
3
Department
of Cardiovascular Medicine, University Hospital of
Mnster, Mnster, Germany,
4
Department
of Pathology and Laboratory Medicine, University of
California, Davis Medical Center, Sacramento,
California, United States,
5
Department
of Internal Medicine, University of Utah, Salt Lake
City, Utah, United States,
6
CARMA,
Department of Internal Medicine, University of Utah,
Salt Lake City, Utah, United States
While post-contrast cardiac T1 has been shown to be
inversely correlated with interstitial fibrosis, it may
be influenced by various confounders. Despite the
theoretical advantages of extracellular volume (ECV)
measurement for compensating confounders, systematic
studies comparing post-contrast T1 and ECV are lacking.
We sought to compare the effectiveness of post-contrast
cardiac T1 and ECV for evaluating the temporal changes
of left ventricular (LV) fibrosis in canine models with
chronic atrial fibrillation. Compared with histologic
quantification of interstitial fibrosis, ECV agreed
better than post-contrast LV T1, suggesting that ECV is
a more robust measure of extracellular space than
post-contrast LV T1.
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