Abstract #3825
Infarct size and extracellular matrix remodelling quantification using an elastin specific contrast agent (ESMA) in a model of permanent coronary ligation
Andrea Protti 1 , Xuebin Dong 1 , Ajay Shah 1 , and Rene Botnar 1
1
Kings College London British Heart
Foundation Centre of Excellence, London, UK, United
Kingdom
Dynamic contrast-enhanced MRI (DCE-MRI) plays an
increasingly important role in cardiac imaging . The
dynamics of contrast agent uptake and distribution have
shown high sensitivity and specificity for many
pathological changes that are not detectable by
anatomical imaging. Magnevist Gd-DTPA is one of the most
used clinically approved contrast agents able to
differentiate areas of burden from healthy after
myocardial infarction (MI). Despite being an optimal
tool to delineate the extent of infarction areas,
Magnevist does not provide any insight about remodeling
processes. For this reason, the albumin contrast agent
gadofosveset, trade name Vasovist (from Ablavar), is
used in this work to evaluate similarities and
advantages to Magnevist in an MI mouse model at 7T.
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