Abstract #3805
Interleaved Imaging and Frequency-Selective Spectroscopic Acquisition for in vivo Pyruvate Polarization Monitoring
Justin Y. C. Lau 1,2 , Albert P. Chen 3 , Jennifer Barry 2 , William Dominguez-Viqueira 2 , and Charles H. Cunningham 1,2
1
Department of Medical Biophysics, University
of Toronto, Toronto, Ontario, Canada,
2
Physical
Sciences, Sunnybrook Research Institute, Toronto,
Ontario, Canada,
3
GE
Healthcare, Toronto, Ontario, Canada
The feasibility of interleaved imaging and selective
spectroscopic acquisition for hyperpolarized
13
C
is demonstrated
in
vivo
. The asymmetry of the pyruvate C
2
doublet
has been shown to correlate with the instantaneous
polarization. Combined with a calibration-based
interpretation of measured C
2
asymmetry, this
investigation is a promising step toward hyperpolarized
signal intensity normalization for quantitative
in
vivo
metabolic
image analysis.
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