Abstract #3802
Improved dynamic 3D spiral CSI with interleaved spectral band excitation for metabolic imaging of hyperpolarized [2-13C]pyruvate
Sonal Josan 1 , Jae Mo Park 1 , Ralph Hurd 2 , Daniel Spielman 1 , and Dirk Mayer 1,3
1
Radiology, Stanford University, Stanford,
CA, United States,
2
GE
Healthcare, CA, United States,
3
Diagnostic
Radiology and Nuclear Medicine, University of Maryland,
Baltimore, MD, United States
There has been growing interest recently in using
hyperpolarized [2-13C]pyruvate, to follow the 13C label
into metabolic products including glutamate (in exchange
with α-ketoglutarate in the TCA cycle), citrate, and
acetylcarnitine as well as lactate and alanine. CSI with
[2-13C]Pyr is challenging given the wide spectral
dispersion of the resonances. This work presents an
improved design for 3D CSI with [2-13C]Pyr using
spectrally selective excitation of limited frequency
bands containing a subset of metabolites, and
interleaving different bands to acquire dynamic
metabolic data in vivo in rat liver.
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