Abstract #3795
Spectrally Selective Imaging of Hyperpolarized 13 C Pyruvate with Multi-Echo, Multi-Phase Advance Balanced Steady State Free Precession
Gopal Varma 1 , Xiaoen Wang 1 , and Aaron K Grant 1
1
Radiology, Division of MR Research, Beth
Israel Deaconess Medical Center, Harvard Medical School,
Boston, MA, United States
Balanced steady-state free precession (bSSFP) offers
potential advantages for imaging of hyperpolarized
13
C,
including high signal-to-noise ratio (SNR) and efficient
use of magnetization. Several variants of bSSFP provide
spectroscopically selective images, including multi-echo
methods and techniques that use a variable RF phase
advance. Both approaches have undesirable sensitivity to
off-resonance, and poor conditioning of the
reconstruction can degrade SNR. Here we describe a
multi-echo variable phase advance method that may
provide more robust imaging. The technique is applied to
phantoms and in vivo imaging of pyruvate and its
metabolites, yielding images with 1mm
2
in-plane
resolution, 4mm slice, and peak lactate SNR~30.
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