Abstract #3790
Distribution of sodium concentration in brain using sodium MRI and double inversion recovery proton MRI
Guillaume Madelin 1 , Richard Kline 2 , Ronn Walvick 1 , Christopher Glielmi 3 , Dominik Paul 4 , Heiko Meyer 4 , Mony de Leon 5 , Henry Rusinek 1,5 , and Ravinder R Regatte 1
1
Radiology, New York University Langone
Medical Center, New York, NY, United States,
2
Anesthesiology,
New York University Langone Medical Center, New York,
NY, United States,
3
Siemens
Medical Solutions USA, Inc, New York, NY, United States,
4
Siemens
AG, Erlangen, Germany,
5
Psychiatry,
New York University Langone Medical Center, New York,
NY, United States
A combined 1H-23Na MRI method was implemented at 3T for
measuring apparent total and intracellular sodium
concentrations (aTSC, aISC) in gray and white matter
(GM, WM) in brain in vivo. Sodium images were acquired
with and without fluid suppression by inversion
recovery. A double inversion recovery (DIR) sequence
(1H) was used to create masks of GM and WM which were
applied to the sodium data. Statistical parameters of
distributions of aTSC and aISC values are measured in GM
and WM and revealed non-Gaussian shape. This MRI method
has potential for assessing early metabolic information
in neurodegenerative pathologies non-invasively.
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