Abstract #3776
Correlation of GABA Levels and Motor Performance in Parkinsons disease
Shalmali Dharmadhikari 1,2 , Swaantje Casjens 3 , Benjamin Glaubitz 4 , Martin Lehnert 3 , Clara Quetscher 3 , Anne Lotz 3 , Thomas Brning 3 , Tobias Schmidt-Wilcke 4 , Christian Beste 5 , Beate Pesch 3 , Dirk Woitalla 6 , and Ulrike Dydak 1,2
1
School of Health Sciences, Purdue
University, W Lafayette, Indiana, United States,
2
Department
of Radiology and Imaging Sciences, Indiana University
School of Medicine, Indianapolis, Indiana, United
States,
3
Institute
for Prevention and Occupational Medicine of the German
Social Accident Insurance, Institute of the
Ruhr-Universitt Bochum (IPA), Bochum, Germany,
4
Department
of Neurology, BG-Klinikum Bergmannsheil,
Ruhr-University, Bochum, Germany,
5
Cognitive
Neurophysiology, Department of Child and Adolescent
Psychiatry, University of Dresden, Germany,
6
Neurological
Clinic, St. Josef-Hospital, Ruhr-Universitt Bochum,
Bochum, Germany
Parkinsons disease (PD) is caused by loss of dopamine
in the basal ganglia which in turn affects the
gamma-aminobutyric acid (GABA) and glutamate metabolism
in the motor pathways. This study investigated the
association of GABA and glutamate levels measured by MRS
in the basal ganglia with motor scores obtained in PD
patients in order to understand the implications of such
disruptions on motor performance. Higher thalamic GABA
levels were found to be associated with increasing
tremor and worse motor performance.
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