Abstract #3750
Comparison of N-Acetyl Aspartate and Polyethylene Glycol as Chemical Shift Reference Standards for Proton Magnetic Resonance Spectroscopic Thermometry
Goldie R. E. Boone 1 , Sunil K. Valaparla 1 , Erika M. Ripley 1 , and Geoffrey D. Clarke 1
1
Radiology, University of Texas Health
Science Center at San Antonio, San Antonio, Texas,
United States
Use of the N-acetyl aspartate metabolite for temperature
measurement in vitro has its disadvantages such as a
spectral line overlap and peak inversion and its low
viscosity can cause acquisition artifacts. This study
demonstrates the novel use of polyethylene glycol as a
proton nuclear magnetic resonance spectroscopy
thermometry reference standard for phantom quantitative
magnetic resonance imaging. The temperature dependent
diffusion characteristics of polyethylene glycol can be
adjusted by its inherent spectroscopic temperature
reporting. Future work will develop polyethylene glycol
for use in evaluating diffusion parameters and gradient
performance in multicenter, longitudinal quantitative
magnetic resonance imaging.
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