Abstract #3740
Long-term reproducibility of GABA levels in the occipital cortex of healthy volunteers
Jamie Near 1 , Yi-Ching Lynn Ho 2 , Kristian Sandberg 3,4 , Chathura Kumaragamage 5 , and Jakob Udby Blicher 6
1
Department of Psychiatry, McGill University,
Montral, Qubec, Canada,
2
Department
of Clinical Medicine - Diagnostic Radiology, Aarhus
University, Aarhus, Aarhus, Denmark,
3
Cognitive
Neurosciences Research Unit, Aarhus University Hospital,
Aarhus, Aarhus, Denmark,
4
UCL
Institute of Cognitive Neurosciences, University College
London, London, London, United Kingdom,
5
Biomedical
Engineering, McGill University, Montral, Qubec,
Canada,
6
CFIN,
Aarhus University Hospital, Aarhus, Aarhus, Denmark
In this study, we investigated the long-term
reproducibility of MEGA-PRESS edited magnetic resonance
spectroscopy measurements of GABA in the occipital
cortex of 19 healthy male volunteers. Repeated
measurements were performed over a period of seven
months; a much longer interval than previous GABA
reproducibility studies in the literature, which used
intervals of eight days or less. Across all subjects,
the average coefficient of variation for repeated
measurements was 5.5%, which is similar to the findings
of short-term reproducibility studies. These results
suggest that GABA concentrations in the occipital cortex
are stable over relatively long periods of time.
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