Abstract #3698
Multinuclear ( 19 F + 1 H) high-resolution intravascular MRI of perfluorooctyl bromide (PFOB) microcapsules at 3T
Shashank Sathyanarayana Hegde 1 , Li Pan 2 , Guan Wang 1,3 , Yingli Fu 1 , and Dara Kraitchman 1
1
Radiology, Johns Hopkins University,
Baltimore, Maryland, United States,
2
Siemens
Corporation, Baltimore, Maryland, United States,
3
Electrical
and Computer Engineering, Johns Hopkins University,
Baltimore, Maryland, United States
Fluorine (
19
F) MRI combined with anatomic
proton (
1
H) MRI provides an effective method
for
in
vivo
cell
tracking. Recently, 3T intravascular MRI (IVMRI) probes
have been shown to provide high-resolution (sub-mm)
in
vivo
imaging
capabilities with local signal-to-noise ratios superior
to conventional surface coils. Here, for the first time,
using a 3T IVMRI probe designed for both
1
H
and
19
F
MRI, we show high-resolution (in-plane: 0.2mm
1
H,
0.8mm
19
F) localization of perfluorooctyl
bromide (PFOB) microcapsules in a porcine heart
ex
vivo
. Localization is confirmed by CT imaging of the
radio-opaque microcapsules.
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