Abstract #3664
Feasibility of applying dual injection DCE-MRI technique in liver study
Amy Watkins 1 , Ka-Loh Li 1 , Xiaoping Zhu 1 , and Alan Jackson 1
1
Wolfson Molecular Imaging Centre, University
of Manchester, Manchester, United Kingdom
Mapping kinetic parameters from DCE-MRI traditionally
requires compromise in terms of spatial resolution,
temporal resolution, and volume coverage. This study
investigated feasibility of applying a dual injection
DCE-MRI approach, which has been applied for brain tumor
study, in liver. Combining information content from high
temporal resolution (HTR) and high spatial resolution
(HSR) data in liver produces a high quality HTR AIF,
allowing kinetic mapping the HSR data with full liver
coverage and a voxel size of 2 mm3. The low dose HTR
data can also be advantageously used for kinetic
analysis, e.g., providing more accurate bolus arrival
time (BAT) maps.
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