Abstract #3658
Detecting CA-lys-TFA a synthetized novel trifluorinated bile acid in murine gallbladder using in vivo 19 F MRI
Su Xu 1,2 , Diana Vivian 3 , Kunrong Cheng 4 , Sandeep Khurana 4 , Wenjun Zhu 1,2 , Andrew Marshall 1,2 , Rao Gullapalli 1,2 , James Polli 3 , and Jean-Pierre Raufman 4
1
Department of Diagnostic Radiology and
Nuclear Medicine, University of Maryland School of
Medicine, Baltimore, MD, United States,
2
Core
for Translational Research in Imaging @ Maryland,
Baltimore, MD, United States,
3
Department
of Pharmaceutical Sciences, University of Maryland
School of Pharmacy, Baltimore, MD, United States,
4
Department
of Medicine, University of Maryland School of Medicine,
Baltimore, MD, United States
Using
in
vivo
19
F
MRI, a novel synthesized trifluorinated bile acid
CA-lys-TFA was tested for its ability to concentrate in
the gallbladders of C57BL/6 mice after oral gavage. Mice
orally gavaged with
19
F
labled CA-lys-TFA revealed robust
19
F
signals from the gallbladder
in
vivo
, and correlated with the concentrations
determined independently using LC-MS on
ex
vivo
tissue.
The results from the study suggest that CA-lys-TFA, a
fluorinated non-radioactive bile acid analogue, has
potential for use in MRI to measure
in
vivo
bile
acid transport and diagnose bile acid malabsorption and
other conditions associated with impaired bile acid
transport.
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