Abstract #3616
Longitudinal patterns of diffusion measures in children treated for B-cell Lymphoma
John O Glass 1 , Emily M Paulus 1 , Zoltan Patay 2 , John T Sandlund 3 , and Wilburn E Reddick 1
1
Division of Translational Imaging Research,
St. Jude Children's Research Hospital, Memphis, TN,
United States,
2
Division
of Diagnostic Imaging, St. Jude Children's Research
Hospital, Memphis, TN, United States,
3
Department
of Oncology, St. Jude Children's Research Hospital,
Memphis, TN, United States
This study examined the white matter (WM) integrity of
19 pediatric mature B-cell lymphoma patients without
clinical signs or symptoms of neurotoxicity at five time
points during treatment using fractional anisotropy (FA)
and radial diffusion. FA from a defined region of
interest was plotted for each patient, and two distinct
patterns were found. Eleven patients showed a decrease
in FA followed by a slow return toward baseline,
consistent with demylination / remylination. Eight
patients demonstrated an immediate spike in FA followed
by a return to normal appearing development, possibly
explained by restricted diffusion related to steroid
therapy.
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