Abstract #3607
Investigation of intrahepatic fat and liver glycogen in diet induced fatty liver disease model
Jadegoud Yaligar 1 , Venkatesh Gopalan 1 , Swee Shean Lee 1 , Bhanu Prakash KN 1 , and S Sendhil Velan 1
1
LABORATORY OF MOLECULAR IMAGING, SINGAPORE
BIOIMAGING CONSORTIUM, Singapore, SINGAPORE, Singapore
Hepatic hyperlipidemia and hepatic glycogen content in
insulin resistant non-alcoholic fatty liver model will
help in understanding the early metabolic changes in
liver metabolism. In this study we have evaluated the
liver fat and glycogen content in non-alcoholic fatty
liver using a diet induced insulin resistant rat model
and compared with normal liver by in vivo and ex vivo
MRS. Our preliminary studies show that the reduction in
glycogen content in fatty liver compared to normal liver
might be due to low glycogen synthase defects under
hyperlipidemia and insulin resistant condition. Liver
fat content in fatty liver is inversely correlated with
glycogen indicating the impairment in glycogen synthesis
due to lipotoxicity.
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