Abstract #3587
Impact of inversion-recovery fat suppression on hepatic R2* quantitation in transfusional siderosis.
Antonella Meloni 1,2 , J. Michael Tyszka 3 , Alessia Pepe 1 , Massimo Lombardi 1 , and John C Wood 2,4
1
CMR Unit, Fondazione G.Monasterio
CNR-Regione Toscana and Institute of Clinical
Physiology, Pisa, Italy,
2
Department
of Pediatrics, Division of Cardiology, Childrens
Hospital Los Angeles, Los Angeles, California, United
States,
3
Division
of Biology, California Institute of Technology,
Pasadena, California, United States,
4
Department
of Radiology, Childrens Hospital Los Angeles, Los
Angeles, California, United States
This represents the first study to compare the impact of
fat saturation prepulse on R2* quantitation in
transfusional siderosis. We demonstrate that SPIR fat
suppression systematically lowered R2* estimates by 3.9%
7.0, and introduced comparable random uncertainty
between the two measurements. Since calibration curves
have been derived using non-fat saturated images, these
biases should be corrected when reporting LIC values
from fat saturated images.
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