Abstract #3487
Measurement of distinctive features of Cortical Spreading Depolarizations with different MRI contrasts
Suryanarayana Umesh Rudrapatna 1 , Arend Hamming 1,2 , Marieke J H Wermer 2 , Annette van der Toorn 1 , and Rick M Dijkhuizen 1
1
University Medical Center Utrecht, Utrecht,
Netherlands,
2
Leiden
University Medical Center, Leiden, Netherlands
Gradient-echo and diffusion-weighted scans have been
used to assess spreading depolarizations (SD) in the
brain, a pathophysiological phenomenon implicated in
various neurological disorders. We evaluated two
alternative MRI techniques, b-SSFP and
diffusion-weighted multi-spin-echo (DT2), in their
potential to improve detection and characterization of
SD in rat brain. b-SSFP, with underpinning spin-echo
contrast, demonstrated higher spatiotemporal specificity
than gradient-echo scanning. DT2 scanning, with the
ability to concurrently measure hemodynamic (T
2
)
and cellular changes (ADC), was shown to offer a
multi-parametric means to gain insights into
co-occurring vascular and cellular changes during SD.
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