Abstract #3449
Three-dimensional macromolecular proton fraction mapping of the human cervical spinal cord
Vasily L. Yarnykh 1
1
Department of Radiology, University of
Washington, Seattle, WA, United States
Macromolecular proton fraction (MPF) is a key parameter
determining the magnetization transfer effect. Based on
recent animal and clinical brain imaging studies, MPF
has attracted significant interest as a biomarker of
myelin. This study demonstrates the feasibility of
quantitative MPF mapping of the human spinal cord in
vivo. A recently published single-point MPF mapping
method was adapted to the spinal cord imaging with
improved time efficiency and SNR performance. 3D MPF
maps of the human cervical spinal cord were obtained
with 1x1x2 mm resolution and ~20 minutes scan time and
demonstrated exceptionally strong contrast between white
and gray matter structures.
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