Abstract #3434
Brain Changes on DTI and ASL in patient with vitamin B12 deficiency while on therapy
Bhaswati Roy 1 , Rakesh K Gupta 1 , Pradeep Kumar Gupta 2 , Ravindra Kumar Garg 2 , Yogita Rai 3 , Hardeep Singh Malhotra 2 , and Chandra M Pandey 4
1
Radiology & Imaging, Fortis Memorial
Research Institute, Gurgaon, Haryana, India,
2
Neurology,
King George's Medical University, Lucknow, Uttar
Pradesh, India,
3
Radiodiagnosis,
Sanjay Gandhi Post Graduate Institute of Medical
Sciences, Lucknow, Uttar Pradesh, India,
4
Biostatistics
& Health Informatics, Sanjay Gandhi Post Graduate
Institute of Medical Sciences, Lucknow, Uttar Pradesh,
India
To evaluate brain changes on DTI and ASL in patient with
vitamin B12 deficiency while on therapy, 16
patients(baseline and after 2-months therapy) and 16
age-and-sex matched controls were enrolled. Voxel-wise
analysis and TBSS analysis were performed for comparing
pre-and post-therapy changes in CBF and FA values
respectively. Significant increase in CBF in GM and
significant decrease in WM after therapy was observed
however pre-and post-therapy FA changes were not
significant. Alteration in the CBF values following
treatment with no significant changes in the FA values
suggest that CBF change may be an early predictor of
recovery than FA.
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