Abstract #3420
Dynamic evolution of atrophy after traumatic brain injury
Christian Ledig 1 , Virginia Newcombe 2 , Guy Williams 3 , Joanne Outtrim 2 , Anne Manktelow 2 , Peter Hutchinson 4 , Jonathan Coles 2 , Daniel Rueckert 5 , and David Menon 2
1
Department of Computing, Imperial College,
London, London, London, United Kingdom,
2
Division
of Anaesthesia, Cambridge University, Cambridge,
Cambridgeshire, United Kingdom,
3
Wolfson
Brain Imaging Centre, Cambridge University, Cambridge,
Cambridgeshire, United Kingdom,
4
Academic
Department of Neurosurgery, Cambridge University,
Cambridgeshire, United Kingdom,
5
Department
of Computing, Imperial College, London, London, United
Kingdom
Traumatic brain injury (TBI) is a major cause of
morbidity and mortality worldwide. It is clear that much
of the sequelae are not just a direct consequence of the
acute event represent a dynamic process with changes
continuing to occur months to years after the
precipitating injury. In this study, longitudinal
changes in brain structures known to be important after
TBI are presented. The differential effects of volume
change are consistent with progressive but selective
damaging effects of TBI indicating that individual
regions have different vulnerabilities to the effects of
injury.
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