Abstract #3403
Investigation of Susceptibility Contrast in Grey and White Matter Multiple Sclerosis Lesions
Cynthia Wisnieff 1,2 , Ryan Brown 3 , David Pitt 4 , and Yi Wang 1,2
1
Biomedical Engineering, Cornell University,
Ithaca, New York, United States,
2
Radiology,
Weill Cornell Medical College, New York, New York,
United States,
3
Radiology,
New York University, New York, New York, United States,
4
Neurology,
Yale University, New Haven, Connecticut, United States
This work examines the susceptibility properties of ex
vivo MS brain specimens with quantitative susceptibility
mapping (QSM). QSM reveals the diamagnetic properties of
cortical lesions and increased paramagnetic properties
of white matter lesions. Changes in both white matter
and grey matter tissue properties are linked to the
pathogenic process in multiple sclerosis (MS). This
preliminary data demonstrates the ability of QSM to
detect WM and GM lesions compared to other gradient echo
based methods and assesses changes in susceptibility
within both white matter and grey matter lesions
compared to normal appearing tissue.
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