Abstract #3374
PATTERNS OF REGIONAL GRAY MATTER AND WHITE MATTER ATROPHY IN CORTICAL MULTIPLE SCLEROSIS
Maria A. Rocca 1 , Laura Parisi 1 , Flavia Mattioli 2 , Ruggero Capra 3 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Clinical Neuropsychology, Spedali
Civili of Brescia, Brescia, BS, Italy,
3
MS
Centre, Spedali Civili of Brescia, Brescia, BS, Italy
Voxel-based morphometry was used to assess the patterns
of regional atrophy of the brain gray matter (GM) and
white matter (WM) in patients with cortical variant of
multiple sclerosis (cort-MS) in comparison to patients
with classic MS (c-MS). Compared to c-MS, cort-MS
patients had GM atrophy of fronto-temporal-parietal
areas and cingulum and WM atrophy of cingulum, bilateral
brainstem and associative fiber bundles. GM and WM
atrophy of key brain regions known to be related to
cognitive functions contribute to differentiate cort-MS
from c-MS. Higher susceptibility to neurodegenerative
processes in these areas could underlie the clinical
presentation of this disease form.
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