Abstract #3337
High Resolution, Motion Corrected Mapping of Macromolecular Proton Fraction (MPF) In Clinically Acceptable Time Using 3D Undersampled Radials
Alexey Samsonov 1 , Pouria Mossahebi 2 , Ashley Anderson 3 , Julia Velikina 4 , Kevin M. Johnson 4 , Sterling C Johnson 5 , John O Fleming 6 , and Aaron Field 7
1
Radiology, University of Wisconsin, Madison,
United States, United States,
2
Biomedical
Engineering, University of Wisconsin, Madison, United
States, United States,
3
Medical
Physics, University of Wisconsin, Madison, WI, United
States,
4
Medical
Physics, University of Wisconsin, Madison, Wisconsin,
United States,
5
Medicine,
University of Wisconsin, Madison, Wisconsin, United
States,
6
Neurology,
University of Wisconsin, Madison, Wisconsin, United
States,
7
Radiology,
University of Wisconsin, Madison, Wisconsin, United
States
Two-pool modeling of magnetization transfer (MT) effects
yields a unique set of measures sensitive to different
tissue composition properties. The key parameter of
interest in this model is a macromolecular pool fraction
(MPF), a potential biomarker of myelin in neural
tissues. However, traditional MPF mapping within
clinical scan time is a relatively low-resolution
methodology. The purpose of this work was to develop a
clinically feasible, high resolution, motion corrected
MPF mapping protocol compatible with clinical standards
for GM assessment (~1 mm isotropic, under 30 min).
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