Abstract #3275
Validations of Quantitative Susceptibility Mapping in Excised Human Cerebral Cavernous Malformation Lesions and in Mice
Huan Tan 1 , Changbin Shi 1 , Abdul Ghani Mikati 1 , Robert Shenkar 1 , Tian Liu 2 , Yi Wang 3,4 , Pottumarthi V Prasad 1,5 , Robert R Edelman 5,6 , and Issam Awad 1
1
University of Chicago, Chicago, IL, United
States,
2
MedImageMetric
LLC, New York, NY, United States,
3
Weill
Cornell Medical College, New York, NY, United States,
4
Cornell
University, Ithaca, NY, United States,
5
NorthShore
University HealthSystem, Evanston, IL, United States,
6
Northwestern
University Feinberg School of Medicine, Chicago, IL,
United States
In this study, we validated quantitative susceptibility
mapping (QSM) in two ex-vivo studies. First, we
correlated QSM results in human cerebral cavernous
malformation (CCM) lesion specimens against mass
spectroscopy. Second, we compared lesional
susceptibility distribution with histology in CCM mice.
The preliminary results demonstrated the excellent
sensitivity and specificity of QSM to identify and
quantify lesional iron content in CCM.
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