Abstract #3269
Tract-based Atlas for Automatic Analysis of Magnetic Susceptibility in Human Brain White Matter
Xue Xiao 1,2 , Wei Li 2 , Kui Ying 3 , and Chunlei Liu 2,4
1
Department of Biomedical Engineering,
Tsinghua University, Beijing, Beijing, China,
2
Brain
Imaging & Analysis Center, Duke University, Durham, NC,
United States,
3
Department
of Engineering Physics, Tsinghua University, Beijing,
China,
4
Department
of Radiology, Duke University, NC, United States
The analysis of white matter in Quantitative
Susceptibility Mapping (QSM) is complicated as white
matter is heterogeneous due to different fiber. To
utilize QSM in population based imaging analysis, a
normalized brain atlas of QSM is needed. We developed
such an atlas for automatic analysis of magnetic
susceptibility in white matter and proposed a method for
white matter analysis of the whole brain. The atlas was
employed to investigate magnetic susceptibility
anisotropy according to a sine-squared relationship with
the fiber orientation. Results indicated a generally
negative relation between magnetic susceptibility and
contribution of myelin in white matter, and the
fiber-track-based atlas was found to be more useful for
anisotropy analysis of the white matter compared to
region-based atlas.
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