Abstract #3214
High Resolution T1 Mapping of the Full Brain with a Modified DESPOT1-HIFI Approach at 7T
Mathies Breithaupt 1 , Sebastian Flassbeck 1 , Moritz C. Berger 1 , and Armin M. Nagel 1
1
Medical Physics in Radiology, German Cancer
Research Center (DKFZ), Heidelberg, Germany
In this work, a modification to the DESPOT1-HIFI
approach for applications at ultra-high magnetic field
strengths of 7T is presented. By simulation of the
mprage sequence via numerically solving the Bloch
equations, the magnetization prior to the inversion can
be approximated. This way, one parameter can be called
from a lookup table inside the non-linear least squares
minimization routine simplifying the target function.
Three-dimensional T1 maps of the whole head with an
isotropic resolution of 1 mm can be acquired within a 25
minute timeframe, revealing T1 values of 1246
43
ms (gray matter) and 1904
48
ms (white matter).
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