Abstract #3154
NOE-CEST and amineproton exchange imaging of mouse brain with suppression of MTC effects
Jiadi xu 1,2 , Kannie W. Y. Chan 1,2 , Xiang Xu 1,2 , Nirbhay Yadav 1,2 , Guanshu Liu 1,2 , Michael T. McMahon 1,2 , and Peter C. M. van Zijl 1,2
1
Radiology Department, Johns Hopkins
University, Baltimore, MD, United States,
2
Kennedy
Krieger Institute, Baltimore, MD, United States
A new CEST scheme was developed using the variable delay
multi-pulse train CEST (VDMP-CEST) in which the
semi-solid magnetization transfer contrast (MTC)
contribution was removed based on its exchange rate. The
scheme requires acquisition of two images: one at zero
inter-pulse delay and a second with an inter-pulse delay
at which the MTC signal is comparable to that at zero
delay. Consequently, subtracting the two images removes
MTC. In addition, direct saturation is reduced, while
CEST contrast in different exchange rate regimes remains
preserved. The new method is demonstrated on phantoms
and on normal mouse brain.
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