Abstract #3152
Multi-pool CEST imaging of glioblastoma at 7 T
Jan-Eric Meissner 1 , Johannes Windschuh 1 , Moritz Zaiss 1 , Daniel Paech 2,3 , Alexander Radbruch 2,3 , and Peter Bachert 1
1
Department of Medical Physics in Radiology,
German Cancer Research Center, Heidelberg, Germany,
2
Department
of Neuroradiology, University of Heidelberg Medical
Center, Heidelberg, Germany,
3
Neurooncologic
Imaging, Department of Radiology, German Cancer Research
Center, Heidelberg, Germany
Chemical Exchange Saturation Transfer (CEST) enables
indirect imaging of metabolites
in
vivo
via
magnetization transfer between exchanging protons of
functional groups and water protons. We propose and
evaluate a 2D-CEST sequence with high spectral sampling
which allows for pixel-wise detection and separation of
NOE-, amides-, and amine-mediated CEST effects and MT
simultaneously by the use of a multi Lorentzian fit.
Especially isolated amide and NOE mapping allowed
insights into glioblastoma substructure.
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