Abstract #3111
Functional MRI and deep-brain stimulation: Impact from distortion artifacts
tefan Holiga 1 , Karsten Mueller 1 , Duan Urgok 2 , Robert Jech 3 , and Harald E. Mller 1
1
Nuclear Magnetic Resonance Unit, Max Planck
Institute for Human Cognitive and Brain Sciences,
Leipzig, Germany,
2
Department
of Radiation and Stereotactic Neurosurgery, Na Homolce
Hospital, Prague, Czech Republic,
3
Department
of Neurology and Center of Clinical Neuroscience, First
Faculty of Medicine, Charles University in Prague, Czech
Republic
Deep-brain stimulation (DBS) is a rapidly evolving
neurosurgical treatment approach for a variety of
disabling neurological and psychiatric symptoms,
offering a range of fundamental research questions.
Several functional MRI (fMRI) studies already revealed
neural correlates of its striking therapeutic benefit on
patients with fully-implanted and active DBS-hardware
under strictly controlled safety standards. In this work
we underline the importance of adhering to rigorous
data-analysis standards, too. In particular, we
demonstrate the DBS-hardware-related signal distortion
artifact problem empirically, present the risk of
false-positive fMRI findings and accordingly call for
extremely cautious means of analyzing fMRI of patients
with implanted electrodes.
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