Abstract #3106
Acquisition of Basal and Evoked Potential CBF Response During Hyperbaric Exposure
Damon P Cardenas 1 , Eric Muir 1 , Shiliang huang 2 , and Timothy Duong 1
1
Radiology, University of Texas Health
Science Center at San Antonio, San Antonio, Texas,
United States,
2
MRI,
Research Imaging Institute, San Antonio, Texas, United
States
There are substantial interests in the effects of oxygen
availability on neurovascular coupling and the response
of cerebral blood flow (CBF) to neural activation. We
evaluated forepaw-evoked CBF responses in rats under i)
normobaric air, ii) normobaric oxygen, iii) hyperbaric
air, and iv) hyperbaric oxygen (HBO). Basal CBF was not
different under the four conditions, despite substantial
increase of oxygen. Stimulus-evoked CBF was increased at
moderately high [O2] compared to normobaric air, but
returned to normal at very high [O2] under HBO,
suggesting CBF responses are in some way regulated by
oxygen-sensitive mechanisms.
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