Abstract #3091
New model and confirmatory measurement of the BOLD hemodynamic response function
Jung Hwan Kim 1 and David Ress 1,2
1
Neuroscience, Baylor College of Medicine,
Houston, TX, United States,
2
Neuroscience,
The University of Texas at Austin, Austin, TX, United
States
We present a novel convection-diffusion oxygen transport
model to understand the BOLD hemodynamic response
function (HRF). A lumped-linear flow model described the
CBF response produced by arterial dilation. The CMRO2
response was assumed to have a gamma-function form. The
model successfully fit the HRF evoked in human visual
cortex and measured using high-resolution fMRI. Results
show how CBF and CMRO2 compete with each other to shape
the BOLD HRF. The predicted flow and CMRO2 amplitudes
agree with previous measurements. Our model provides a
detail theoretical framework to understand neurovascular
and neurometabolic coupling in the brain.
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