Abstract #3083
Altered Brain Connectivity during Abstinence in a rat model of Alcoholism investigated with MEMRI and rsfMRI
Wolfgang Weber-Fahr 1 , Claudia Falfn-Melgoza 1 , Marcus Meinhardt 2 , Sandra Dieter 2 , Santiago Canals 3 , Alexander Sartorius 1 , and Wolfgang Sommer 2
1
RG Translational Imaging, Central Institute
of Mental Health, Medical Faculty Mannheim, University
of Heidelberg, Mannheim, Germany,
2
Department
of Psychopharmacology, Central Institute of Mental
Health, Medical Faculty Mannheim, University of
Heidelberg, Mannheim, Germany,
3
CSIC-UMH,
Instituto de Neurociencias, Sant Joan d'Alacant, Spain
In this study we aimed to investigate the brain networks
in a rat model of alcohol abstinence with MEMRI and
rsfMRI. 21 rats of which 11 underwent 8 weeks of Ethanol
exposure were scanned after 2 week withdrawal at a 9.4T
scanner. Additionally to rsfMRI; T1-maps were acquired
for 12 rats before and after subcutanious osmotic Mn2+
pump implantation. ICA showed an increased interoceptive
network component in the cingulate cortex of rats in
withdrawal. Even though both methods rely on
fundamentally different approaches, an overlapping area
of increased Mn2+ uptake was found in the MEMRI data.
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