Abstract #2987
Evaluation of Point Spread Function and Functional Sensitivity of 3D-GRASE and 2D Spin-Echo EPI for Sub-Millimeter-Resolution fMRI at 7 T
Valentin G. Kemper 1 , Federico De Martino 1 , An T. Vu 2 , Benedikt A. Poser 1 , David A. Feinberg 3,4 , Essa Yacoub 2 , and Rainer Goebel 1
1
Department of Cognitive Neuroscience,
Maastricht University, Maastricht, Limburg, Netherlands,
2
Radiology,
Center for Magnetic Resonance Research, University of
Minnesota, Minneapolis, Minnesota, United States,
3
Helen
Wills Institute of Neuroscience, University of
California, Berkeley, United States,
4
Advanced
MRI Technologies, California, United States
3D Inner Volume GRASE (3D-GRASE) and Spin-Echo EPI (2D
SE-EPI) sequences were compared with regard to
sensitivity and resolution in the context of
sub-millimeter functional MRI at 7 T. Theoretical
simulations, acquisitions with phase encoding turned
off, and analysis of residual noise correlations showed
that the point spread in slice direction in 3D-GRASE is
comparable to the point spread of 2D SE-EPI in phase
encoding direction with commonly employed acquisition
parameters and reconstructions. t-values of functional
activity in a simple visual activation experiment were
higher in 3D-GRASE acquisitions due to better temporal
signal to noise ratio.
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