Abstract #2973
1 H-[ 13 C]-NMR Study of Cerebral Energy Metabolism under sub-Acute Exposure of Aluminium Chloride in Mice: Implications for Dementia
Anant Bahadur Patel 1 , Pandichelvam Veeraiah 1 , and Vivek Tiwari 1
1
NMR Microimaging and Spectroscopy,
CSIR-Centre for Cellular and Molecular Biology,
Hyderabad, Andhra Pradesh, India
Although aluminium has been linked to dementia type
diseases including Alzheimers and Parkinsons disease
in molecular aspects, the cerebral energy metabolism
associated with glutamatergic and GABAergic neurons with
aluminium exposure remains elusive. In this study, we
have investigated the glutamatergic and GABAergic
metabolism in the cerebral cortex, hippocampus and
striatum regions of mice under sub-acute exposure of
aluminium chloride by using
1
H-[
13
C]-NMR
spectroscopy together with infusion of [1,6-
13
C
2
]glucose.
Both, glutamatergic and GABAergic metabolism were found
to be enhanced in aluminium chloride treated mice, which
may be due to inflammatory response of aluminium
toxicity in brain.
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