Abstract #2969
Chronic Exposure to Lead Impairs Neuronal Metabolism in Mouse Brain: A 1 H-[ 13 C]-NMR Study
Anant Bahadur Patel 1 , K.S. Varadarajan 1 , Puneet Bagga 1 , and Anup Nirmal Chugani 1
1
NMR Microimaging and Spectroscopy,
CSIR-Centre for Cellular and Molecular Biology,
Hyderabad, Andhra Pradesh, India
Lead is a highly poisonous heavy metal with widespread
use in construction and industries. Chronic exposure to
lead has shown to cause systemic damage leading to
permanent cognitive and behavioral impairment.
Glutamatergic and GABAergic neuro-energetics were
evaluated in the cerebral cortex and hippocampus of
adult male C57BL6 mice using
1
H-[
13
C]-NMR
spectroscopy in conjunction with infusion of [1,6-
13
C
2
]glucose.
Glutamatergic neuronal activity was found to be reduced
in the cortical and hippocampal regions due to chronic
lead toxicity while GABAergic function was perturbed
only in the hippocampus.
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