Abstract #2956
Investigating Longitudinal Metabolite Changes Associated with Epileptogenesis in vivo in a Rat Model of Interictal Spiking Using H MRS at 7 Tesla
Helen Wu 1 , Danielle Senador 2 , Matthew Galloway 3 , Jeffrey Loeb 2,4 , and Jeffrey Stanley 5
1
Psychiatry and Behavioral Neurosciences,
Wayne State University School of Medicine, Detroit, MI,
United States,
2
Center
for Molecular Medicine and Genetics, Wayne State
University School of Medicine, MI, United States,
3
Psychiatry
and Behavioral Neurosciences, Wayne State University,
MI, United States,
4
Neurology,
University of Illinois at Chicago, IL, United States,
5
Psychiatry
and Behavioral Neurosciences, Wayne State University
School of Medicine, MI, United States
We used a chronic tetanus toxin rat model of interictal
spiking as a platform to investigate longitudinal
metabolite changes associated with epileptogensis. Our
1H MRS performed in vivo at 7T provides the opportunity
to examine neocortical metabolite changes associated
with the epileptogenic process in context of concurrent
long term EEG changes. The goal of this study is to
identify key biomarkers associated with epileptogensis
in the neocortex, which we believe exhibits a different
pattern of metabolite level changes than those observed
in the hippocampus. Identification of such markers can
help guide future clinical and pharmacological
approaches.
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