Abstract #2940
Alterations of GABA levels in premenstrual syndrome women: A proton magnetic resonance spectroscopy study.
Bo Liu 1 , Bin Zhao 1 , Guangbin Wang 1 , and Fei Gao 1
1
Shandong Medical Imaging Research Institute,
Shandong University, Jinan, Shandong, China
Most women of reproductive age suffer from premenstrual
syndrome(PMS) ,which is affecting their daily life
.Evidences have shown the involvement of
gamma-aminobutyric acid(GABA) neurotransmitter system in
PMS. In this study , significantly reduced GABA levels
were observed in PMS women in the anterior cingulate
cortex (ACC)/medial prefrontal cortex (mPFC) ,whereas no
difference was found in ltBG. The ACC/mPFC was suggested
to be involved in negative emotions and in modulation of
automatic nervous systems, and dysfunctions in this
region may partly underlie the variety of psychosomatic
premenstrual symptoms. Premenstrual GABA deficit may be
an important neurobiological mechanism contributing to
the pathophysiology of PMS.
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