Abstract #2935
Cerebral Phosphorus Metabolites Profiling of Parkinsons Disease Patients at 7T
Xiao-Hong Zhu 1 , Byeong-Yeul Lee 1 , Susan Rolandelli 2 , Paul Tuite 2 , and Wei Chen 1
1
CMRR, Department of Radiology, University of
Minnesota Medical School, Minneapolis, MN, United
States,
2
Department
of Neurology, University of Minnesota Medical School,
MN, United States
Parkinsons disease (PD) is the second most common
neurodegenerative disorder, which affects men slightly
more often than women. Mitochondrial dysfunction has
been suspected as a pathogenic mechanism of PD. However,
direct in vivo evidence of mitochondrial abnormalities
and accompanying impairments in energy metabolism is
incomplete in PD. Fortunately with developments of
in
vivo
31
P
MRS at 7 tesla, it is now possible to obtain high
quality quantitative cerebral phosphorus metabolite
profiles which give insight into brain metabolism. In
our evaluation of individuals with PD and matched
controls we demonstrated significant differences between
male and female PD subjects in the phosphorus metabolite
profiles. These preliminary findings highlight the
feasibility of this non-invasive MR method that may
further understanding of PD as well as potential gender
effects on the disease.
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