Abstract #2926
Co-registered EPR and MRI of the mouse head indicates detailed distributions of piperidine nitroxides
Miho C Emoto 1 , Hideo Sato-Akaba 2 , Hiroshi Hirata 3 , and Hirotada G Fujii 1
1
Sapporo Medical University, Sapporo,
Hokkaido, Japan,
2
Osaka
University, Osaka, Japan,
3
Hokkaido
University, Hokkaido, Japan
Piperidine nitroxides such as TEMPONE and TEMPOL are
useful redox-sensitive probes for redox research, but
due to their short lifetime in vivo, they have not been
fully employed in EPR imaging studies. In this study, we
developed an improved EPR imaging system with a
rapid-field scanning capability, and obtained
three-dimensional EPR images of piperidine nitroxides in
mouse heads in 15 s. The co-registered EPR and MRI
images of mouse heads clearly depict detailed
distributions of TEMPONE. With this improved EPR imaging
system, it is likely that piperidine nitroxides can be
used to estimate redox status in in vivo systems.
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