Abstract #2910
Optimal scan time for reproducible GABA measurements
Alexander R Craven 1 , Renate Grner 2,3 , Lars Ersland 4 , Gerard E Dwyer 1 , Maiken Kirkegaard Brix 1,2 , and Kenneth Hugdahl 1,5
1
Department of Biological and Medical
Psychology, University of Bergen, Bergen, Norway,
2
Department
of Radiology, Haukeland University Hospital, Bergen,
Norway,
3
Department of Physics and Technology,
University of Bergen, Norway,
4
Department
of Clinical Engineering, Haukeland University Hospital,
Bergen, Norway,
5
Division
of Psychiatry, Haukeland University Hospital, Bergen,
Norway
Despite increasing usage of the MegaPRESS GABA-editing
MRS sequence for measurement of GABA concentrations in
the human brain, optimal values for some basic sequence
parameters such as the number of repetitions (hence,
scan time) have not been established in literature. The
present investigation examines the effects of increasing
scan time on reproducibility, leading to a
recommendation of 256 averages (13 minutes) as a
starting point. Furthermore, an upper limit on scan time
to 20 minutes is recommended, whereafter cumulative
disturbances begin to outweigh gains in signal quality.
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